Question
Is it possible to disable the Let's Encrypt certificate auto-renewal on a Plesk server?
Answer
It's not possible to disable the Let's Encrypt certificate auto-renewal for the particular domain.
To disable the Let's Encrypt certificate renewal for all domains:
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Go to Tools & Settings > Scheduled Tasks. 
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Find the Extension letsencrypt and/or Extension sslit tasks keep-secured.phpand click on the green dot to disable the task: to disable the task: Note: this will also disable the automatic certificate renewal for the Plesk login page and mail server.