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Plesk for Linux since version 11.5 supports third-party builds and variants of MySQL server, PHP packages and PHP-FPM. For example, you may install MariaDB or Percona Server in place of OS vendor [...]

Plesk uses MySQL as both admin and client RDBMS. Plesk 11.5 for Linux and higher allows for MySQL alternatives (such as MariaDB or Percona Server) to be used as drop-in replacements for it. [...]